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Nicotinamide Mononucleotide (NMN) May Be the Miracle Cure for Aging

From Ponce de Leon and the Fountain of Youth to "miracle cures" for aging, the search for immortality is as old as humanity. As scientists delve deeper into our genetic code, more information has been revealed about cellular aging and death. While immortality is not possible, we have more ways than ever to delay the impact of aging. Nicotinamide mononucleotide (NMN), discovered in the 1960s, maybe another key to prolonging life.

Nicotinamide mononucleotide (NMN) is a substance made by our bodies that are converted into nicotine adenine dinucleotide (NAD). NAD is required by all cells to provide energy and regulate critical survival functions. NAD cannot be readily absorbed into the body but must be manufactured from precursors like NMN, tryptophan, and nicotinamide. Unfortunately, over time, NMN and, subsequently, NAD levels decline as part of the aging process.

The role of NMN in the body

NMN, which is a derivative of vitamin B3 (niacin), controls several functions in the body. It is responsible for energy production and metabolism, cell growth, regulation of inflammation and response to oxidative stress, DNA repair, and gene expression. Without NMN, cells will die.

Aging and NMN levels

With age, NMN is not produced at the same capacity as during youth. This age-related decrease in NMN occurs in all organ systems. NMN also declines prematurely as a result of UV damage. UV rays trigger the enzyme poly ADP-ribose polymerase to repair DNA damage, which consumes large amounts of NAD and NMN.

Consuming NMN

All cells in the body manufacture NMN, but this manufacturing decreases with age. NMN can also be supplemented by consuming certain foods and oral supplements like Hello100. Foods that contain high levels of NMN include avocado, broccoli, cabbage, tomato, cow's milk, cucumber, and edamame. More studies must be conducted to provide minimum and maximum dose safety guidelines for NMN supplements. Studies are currently being conducted to determine if topical preparations can deliver NMN directly to skin cells.

Benefits of NMN

Animal models have demonstrated the health benefits of NMN across several different organ systems. Some potential benefits include:

  • Preventing cancer by repairing damaged DNA.
  • Protecting brain cells from damage that can lead to Alzheimer disease.
  • Reversing arterial damage to prevent heart disease.
  • Regulating insulin sensitivity to prevent diabetes.
  • Increasing muscle strength and endurance.
  • Protecting cells from UV damage.

NMN and UV damage

UV light is the number one cause of premature skin aging. NMN is a powerful antioxidant that scavenges up free radicals produced by the sun that attack our cells and destroy our collagen and elastin. Collagen and elastin destruction leads to wrinkles and sagging skin. NMN also repairs damage that UV light causes to our DNA. DNA damage leads to skin cancer formation. NMN also reduces the inflammation caused by UV damage that leads to skin aging.

Side effects and dosing

In the few studies conducted so far, there have been minimal to no side effects from NMN supplementation, and there was little impact on laboratory values. Studies have shown the dosing of NMN at 250–1200 mg daily. More studies need to be conducted to pinpoint accurate dosing while minimizing side effects.

NMN has the potential for enormous health benefits. Study results have shown benefits in many organ systems, including the skin. While more studies need to be conducted, NMN could be another tool to revolutionize the aging process.

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