Children seizures and Cannabis: ten days on THC oil 2014

It’s been ten days since Barbara started her daughter, Nova Leigh, on THC cannabis oil. Ten days without a seizure. When one did come, another dose of the oil and it stopped almost immediately.

Barbara’s daughter, Nova Leigh, suffers from a rare birth defect called Shizencehaly. She was also born without a thyroid and only 25% of her brain developed.

Everyone told Barbara that cannabis could not possibly help Nova, but it did.
Here is Barbara’s account of the ten days following cannabis oil therapy.

We’re CPN Institute. We’re a national, cannabis educational organization, empowering patients to take a leading role in their healthcare.

Click on the video to watch.

Source: Youtube
Posted by The Health Cure, January 3 2018

The Science of Cannabis as a Treatment for Epilepsy

The Science of Cannabis as a Treatment for Epilepsy

What to do about the medical use of marijuana (cannabis) as a potential treatment for a number of neurologic conditions, including epilepsy, is a hotly debated issue. There are legal issues surrounding access to cannabis, as well as a lack of scientific research on the usefulness and safety of marijuana as a treatment for seizures. Additionally, many different substances containing cannabis are being used which makes it difficult to study.

Does cannabis help seizures?

Evidence from laboratory studies, anecdotal reports, and small clinical studies from a number of years ago suggests that cannabidiol, a non-psychoactive compound of cannabis, could potentially be helpful in controlling seizures. However, there are conflicting reports in the literature. So far, scientifically controlled studies have not shown definitive proof of the effectiveness and safety of marijuana or cannabis in epilepsy. For example, in 2012, a literature review of clinical studies on cannabinoids for epilepsy could not give a reliable conclusion about the effectiveness of four randomized controlled trials of cannabidiol. Yet in the 48 people included in these reports, no side effects were noted. Conducting studies can be difficult as researchers have limited access to marijuana due to federal regulations and even more limited access to cannabidiol; there are also increased financial and time constraints.

Individual reports of children with refractory (or intractable) epilepsy who have tried cannabis, usually with high ratios of cannabidiol to THC, have reported marked improvements in seizure frequency, including a report describing the results of Charlotte, a girl with Dravet syndrome.

Cannabidiol (CBD): Recently, there have been some open-labeled studies in the U.S. of Epidiolex (a drug derived from cannabidiol or CBD), which is produced by a pharmaceutical company (GW Pharmaceuticals). Epidiolex is a purified, 99% oil-based extract of CBD that is produced to give known and consistent amounts in each dose. The U.S. Food and Drug Administration (FDA) has given some epilepsy centers permission to use this drug as “compassionate use” for a limited number of people at each center. Such studies are ongoing for difficult epilepsies such as Lennox-Gastaut syndrome (in children and adults) and Dravet syndrome in children.

Results from 213 people who received Epidiolex (99% CBD) in an open label study (without a placebo control) were presented at the American Academy of Neurology, April 22, 2015 in Washington DC. Data from 137 people who completed 12 weeks or more on the drug were used to look at how helpful or effective the drug was. People who received the Epidiolex ranged from 2 to 26 years old with an average age of 11. All had epilepsy that did not respond to currently available treatments – 25 or 18% had Dravet Syndrome (DS) and 22 or 16% had Lennox-Gastaut Syndrome (LGS).

  • Seizures decreased by an average of 54% in 137 people who completed 12 weeks on Epidiolex.
  • Patients who had DS responded more positively with a 63% decrease in seizures over 3 months.
  • This improvement in seizures lasted through 24 weeks on the Epidiolex, more often for people with DS than without DS.
  • In 27 patients with atonic seizures (which are commonly seen in people with LGS as well as other types of epilepsy), the atonic seizures decreased by 66.7% on average.
  • The responder rate (the number of people whose seizures decreased by at least 50%) was also slightly better in patients with DS (about 55% at 3 months) as compared to patients without DS (50%).
  • People who were also taking the anti-seizure medication Clobazam (Onfi) seemed to respond more favorably to the Epidiolex with a greater improvement in convulsive seizures than in patients who were not taking Clobazam. The authors suggested that an interaction between Clobazam and Epidiolex may play a part in the differences seen.
  • 14 people withdrew from the study because the drug was not effective for them.

A controlled study on on Epidiolex involving many epilepsy centers is now being done that will compare children with Dravet syndrome or Lennox-Gastaut syndrome taking the active drug with children not receiving the drug.

Source: YouTube
The Health Cure, December 12 2016

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Cannabidiols: Potential Use in Epilepsy & Other Neurological Disorders

Orrin Devinsky Cannabidiol CBD

Cannabidiols: Potential Use in Epilepsy & Other Neurological Disorders

This course will provide an overview of preclinical and clinical data on cannabidiol (CBD), a nonpsychoactive component of cannabis that shows great promise in a variety of neurological disorders. The expert international faculty will discuss uses of CBD in epilepsy, movement disorders, multiple sclerosis, pain disorders, psychiatric disorders, and neonatal hypoxic-ischemic encephalopathy. The pharmacology of plant cannabidiols, and efficacy of CBD in animal models of epilepsy and other disorders will be reviewed. The most up-to-date safety and efficacy data on CBD in normal and neuropsychiatric disorders will be presented. Planned studies to assess the potential role of CBD in treatment-resistant childhood epilepsies and ways to assess disease modification will also be covered.

Source: faces.med.nyu.edu , Youtube
The Health Cure, November 15 2014

Desperate parents turn to medical marijuana in last-ditch effort to improve their children's lives

Desperate parents turn to medical marijuana in last ditch effort to improve their children's livesCheri O’Connell with daughter Tara and son Sean.

Desperate parents turn to medical marijuana in last-ditch effort to improve their children’s lives

PREMIER Denis Napthine says he supports the decision of the medical administration not to legalise medicinal marijuana, even after it has been revealed it saved a young girl’s life.

Victorian mum Cheri O’Connell spoke out about the benefits of liquid marijuana, which she says saved her epileptic daughter who was only given months to live.

“These issues in terms of approving medications are issues for the Therapeutic Goods Administration under the Federal Government,” Dr Napthine said.

“They base their decisions on the best medical advice and science. That’s the way these decisions ought to be based and I support that process.”

Eight-year-old Tara was having up to 60 seizures a day but has made a miraculous recovery since her mother , Cheri started giving her liquid cannabis made in Nimbin.

Continue reading Desperate parents turn to medical marijuana in last-ditch effort to improve their children's lives