The Science of Cannabis as a Treatment for Epilepsy

The Science of Cannabis as a Treatment for Epilepsy

What to do about the medical use of marijuana (cannabis) as a potential treatment for a number of neurologic conditions, including epilepsy, is a hotly debated issue. There are legal issues surrounding access to cannabis, as well as a lack of scientific research on the usefulness and safety of marijuana as a treatment for seizures. Additionally, many different substances containing cannabis are being used which makes it difficult to study.

Does cannabis help seizures?

Evidence from laboratory studies, anecdotal reports, and small clinical studies from a number of years ago suggests that cannabidiol, a non-psychoactive compound of cannabis, could potentially be helpful in controlling seizures. However, there are conflicting reports in the literature. So far, scientifically controlled studies have not shown definitive proof of the effectiveness and safety of marijuana or cannabis in epilepsy. For example, in 2012, a literature review of clinical studies on cannabinoids for epilepsy could not give a reliable conclusion about the effectiveness of four randomized controlled trials of cannabidiol. Yet in the 48 people included in these reports, no side effects were noted. Conducting studies can be difficult as researchers have limited access to marijuana due to federal regulations and even more limited access to cannabidiol; there are also increased financial and time constraints.

Individual reports of children with refractory (or intractable) epilepsy who have tried cannabis, usually with high ratios of cannabidiol to THC, have reported marked improvements in seizure frequency, including a report describing the results of Charlotte, a girl with Dravet syndrome.

Cannabidiol (CBD): Recently, there have been some open-labeled studies in the U.S. of Epidiolex (a drug derived from cannabidiol or CBD), which is produced by a pharmaceutical company (GW Pharmaceuticals). Epidiolex is a purified, 99% oil-based extract of CBD that is produced to give known and consistent amounts in each dose. The U.S. Food and Drug Administration (FDA) has given some epilepsy centers permission to use this drug as “compassionate use” for a limited number of people at each center. Such studies are ongoing for difficult epilepsies such as Lennox-Gastaut syndrome (in children and adults) and Dravet syndrome in children.

Results from 213 people who received Epidiolex (99% CBD) in an open label study (without a placebo control) were presented at the American Academy of Neurology, April 22, 2015 in Washington DC. Data from 137 people who completed 12 weeks or more on the drug were used to look at how helpful or effective the drug was. People who received the Epidiolex ranged from 2 to 26 years old with an average age of 11. All had epilepsy that did not respond to currently available treatments – 25 or 18% had Dravet Syndrome (DS) and 22 or 16% had Lennox-Gastaut Syndrome (LGS).

  • Seizures decreased by an average of 54% in 137 people who completed 12 weeks on Epidiolex.
  • Patients who had DS responded more positively with a 63% decrease in seizures over 3 months.
  • This improvement in seizures lasted through 24 weeks on the Epidiolex, more often for people with DS than without DS.
  • In 27 patients with atonic seizures (which are commonly seen in people with LGS as well as other types of epilepsy), the atonic seizures decreased by 66.7% on average.
  • The responder rate (the number of people whose seizures decreased by at least 50%) was also slightly better in patients with DS (about 55% at 3 months) as compared to patients without DS (50%).
  • People who were also taking the anti-seizure medication Clobazam (Onfi) seemed to respond more favorably to the Epidiolex with a greater improvement in convulsive seizures than in patients who were not taking Clobazam. The authors suggested that an interaction between Clobazam and Epidiolex may play a part in the differences seen.
  • 14 people withdrew from the study because the drug was not effective for them.

A controlled study on on Epidiolex involving many epilepsy centers is now being done that will compare children with Dravet syndrome or Lennox-Gastaut syndrome taking the active drug with children not receiving the drug.

Source: YouTube
The Health Cure, December 12 2016

Medicinal Marijuana, Cannabis Oil, THC Oil, CBD Oil, Rick Simpson, Phoenixtears, Run From The Cure, The Health Cure, CB1, CB2 Receptors, Cannabis Cures Cancer, Epileptic, Seizures, Skincancer, Alzheimer, Glaucoma, Artitis, Endocannabinoid system, www.thehealthcure.org, Indiga, Sativa, Doggs, Cats, Clearing The Smoke

SAVE SHYLOH

SAVE SHYLOH

SAVE SHYLOH

The documentary is about Shyloh. She was born with 100% fatal
brain cancer that gave her severe epilepsy, cerebral palsy, and strokes by
two months old. In the last hours of her life, Shylohs father began treating her with
cannabis to control her seizures and reduce her terrible suffering.

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Cannabidiols: Potential Use in Epilepsy & Other Neurological Disorders

Orrin Devinsky Cannabidiol CBD

Cannabidiols: Potential Use in Epilepsy & Other Neurological Disorders

This course will provide an overview of preclinical and clinical data on cannabidiol (CBD), a nonpsychoactive component of cannabis that shows great promise in a variety of neurological disorders. The expert international faculty will discuss uses of CBD in epilepsy, movement disorders, multiple sclerosis, pain disorders, psychiatric disorders, and neonatal hypoxic-ischemic encephalopathy. The pharmacology of plant cannabidiols, and efficacy of CBD in animal models of epilepsy and other disorders will be reviewed. The most up-to-date safety and efficacy data on CBD in normal and neuropsychiatric disorders will be presented. Planned studies to assess the potential role of CBD in treatment-resistant childhood epilepsies and ways to assess disease modification will also be covered.

Source: faces.med.nyu.edu , Youtube
The Health Cure, November 15 2014

Clearing The Smoke The Science Of Cannabis

clearing-the-smoke

Clearing The Smoke The Science Of Cannabis

Clearing the Smoke, reveals how cannabis acts on the brain and in the body to treat nausea, pain, epilepsy and potentially even cancer.

Extensive interviews with patients, doctors, researchers and skeptics detail the promises and the limitations of medicinal cannabis. Even though the video has an American perspective, marijuana use is illegal throughout many countries of the world for reasons that are not clear.

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20 Medical Studies That Prove Cannabis Can Cure Cancer

Cannabis Medicine 1

20 Medical Studies That Prove Cannabis Can Cure Cancer

Cannabis has been making a lot of noise lately. Multiple states across the United States and countries around the world have successfully legalized medical Marijuana, and the Uruguay parliament recently voted to create the world’s first legal marijuana market. This is good news as the health benefits of Cannabis are vast, with multiple medical and scientific studies that confirm them. On the other hand, arguments against the use of marijuana is usually published in Psychiatric journals, which show no scientific evidence that Cannabis is harmful to human health. All psychological evaluations from the intake of cannabis are largely based on assumptions, suggestions and observations (1). When we look at the actual science behind Cannabis, the health benefits can be overwhelming. So what does one who opposes the use of cannabis base their belief on? Nothing, not scientific evidence anyways. The negative stigmatism attached to marijuana is due to it’s supposed psychotropic effects, yet again, there is no scientific evidence to show that marijuana has any psychotropic effects. Nonetheless, cannabis has recently been the focus of medical research and considered as a potential therapeutic treatment and cure for cancer.

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Today Parents turn to medical marijuana to soothe sick children

Today Parents turn to medical marijuana to soothe sick children

Today Parents turn to medical marijuana to soothe sick children

In 17 states kids are able to get medical marijuana, by prescription, to treat everything from autism to cancer to seizures. Growers are now breeding the plants with low levels of the substance THC, which reportedly helps kids get the medicinal benefits of marijuana without the high. NBC’s Dr. Nancy Snyderman reports.

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Desperate parents turn to medical marijuana in last-ditch effort to improve their children's lives

Desperate parents turn to medical marijuana in last ditch effort to improve their children's livesCheri O’Connell with daughter Tara and son Sean.

Desperate parents turn to medical marijuana in last-ditch effort to improve their children’s lives

PREMIER Denis Napthine says he supports the decision of the medical administration not to legalise medicinal marijuana, even after it has been revealed it saved a young girl’s life.

Victorian mum Cheri O’Connell spoke out about the benefits of liquid marijuana, which she says saved her epileptic daughter who was only given months to live.

“These issues in terms of approving medications are issues for the Therapeutic Goods Administration under the Federal Government,” Dr Napthine said.

“They base their decisions on the best medical advice and science. That’s the way these decisions ought to be based and I support that process.”

Eight-year-old Tara was having up to 60 seizures a day but has made a miraculous recovery since her mother , Cheri started giving her liquid cannabis made in Nimbin.

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CAN CANNABIS CURE CANCER

CAN CANNABIS CURE CANCER

CAN CANNABIS CURE CANCER

The use of cannabis oil as a cure for cancer of various types.

Continue reading CAN CANNABIS CURE CANCER

CT SCANS of a Stg 4 Breast Cancer Patient treated with CANNABIS OIL

CT SCANS of a Stg 4 Breast Cancer Patient treated with CANNABIS OIL

CT SCANS of a Stg 4 Breast Cancer Patient treated with CANNABIS OIL

Continue reading CT SCANS of a Stg 4 Breast Cancer Patient treated with CANNABIS OIL

Hemp oil extract CBD being promoted as alternative health treatment for cancer, epilepsy

Hemp oil extract CBD being promoted as alternative health treatment for cancer, epilepsy

Hemp oil extract CBD being promoted as alternative health treatment for cancer, epilepsy

A 3-year-old Florida girl battling brain cancer is now in San Diego hoping to heal by using a treatment found in a form of marijuana.

Continue reading Hemp oil extract CBD being promoted as alternative health treatment for cancer, epilepsy