The Science of Cannabis as a Cancer Cure (Documentary)
There is a plentiful supply of research articles and personal testaments that show the efficacy of cannabis effecting cancer remission. However, only a few point to the mechanism by which the cancer cells die. To understand this better we need to know what metabolic processes provide life to the cells.
There are two structures in most cells that sustains life; one is the mitochondria, and the other is the endoplasmic reticulum. The mitochondria primarily produces adenosine triphosphate (ATP) that provides the necessary energy. The endoplasmic reticulum (ER) is a loosely bound envelope around the cell nucleus that synthesizes metabolites and proteins directed by the nuclear DNA that nourish and sustain the cell.
Let us look first at tetrahydrocannabinol (THC) and observe that THC is a natural fit for the CB1 cannabinoid receptor on the cancer cell surface. When THC hits the receptor, the cell generates ceramide that disrupts the mitochondria, closing off energy for the cell.
Disruption of the mitochondria releases cytochrome c and reactive oxygen species into the cytosol, hastening cell death. It is notable that this process is specific to cancer cells. Healthy cells have no reaction to THC at the CB1 receptor. The increase in ceramide also disrupts calcium metabolism in the mitochondria, completing the demise to cell death.
The other cannabinoid we know is effective in killing cancer cells is cannabidiol (CBD). The primary job of CBD in the cancer cell is to disrupt the endoplasmic reticulum through wrecking of the calcium metabolism, pushing calcium into the cytosol. This always results in cell death. Another pathway for CBD to effect cancer cell death is the Caspase Cascade, which breaks down proteins and peptides in the cell. When this happens the cell cannot survive. Again, these processes are specific to cancer cells, no normal cells are affected.
Elderly Man with Terminal Cancer Walks Out of Hospice after Treatment with Cannabis Oil
“After nine months of taking two different forms of cannabis oil, one, a cannabis capsule infused with organic coconut oil around 10:30am and high THC oil about an hour before bed, dad was given the life changing report, ”No evidence of recurrent disease”. 
– Corinne Malanca (Stan and Barb Rutner’s daughter)
National Geographic Explorer: Marijuana Nation – Dr. Raphael Mechoulam.
Raphael Mechoulam, while being a junior member at the Weizmann Institute of Science, succeeded in the isolation, structure elucidation and total synthesis of Δ9–tetrahydrocannabinol, the main active principle of marijuana. He later became a full professor for medicinal chemistry at the Hebrew University of Jerusalem where he established the “Department of Natural Products”. His major scientific interest is the chemistry and pharmacology of cannabinoids. He and his research group succeeded in the total synthesis of the major plant cannabinoids Δ9–tetrahydrocannabinol, cannabidiol, cannabigerol and various others. Another research project initiated by him led to the isolation of the first described endocannabinoidanandamide which was isolated and characterized by two of his postdoctoral researchers, Lumír Ondřej Hanuš and William Devane. Another endogenous cannabinoid, 2-AG, was soon discovered by Shimon Ben-Shabat, one of his PhD students. He published more than 350 scientific articles.
Dr. Robert Melamede, Ph.D.
Associate Professor and Biology Chairman
Biology Department at the University of Colorado
CEO and President of Cannabis Science
“Cannabinoids kill cancer cells in many cases, people are not aware of this”
Cannabinoid-1 Receptor Protects The Brain From Aging
Researchers from the Universities of Bonn and Mainz have discovered a mechanism that seems to protect the brain from aging. In experiments with mice, they switched off the cannabinoid-1 receptor. As a consequence, the animals showed signs of degeneration as seen in people with dementia much faster. The research results are presented in a current issue of the Proceedings of the National Academy of Sciences (PNAS).