Curcuma longa linn as anti cancer cell

Curcuma longa linn as anti cancer cell

Curcuma longa linn as anti cancer cell

Curcuma Longa/Cúrcuma is a small perennial herb native to India bearing many rhizomes on its root system which are the source of its culinary spice known as Turmeric (Cúrcuma – rizoma secco in polvere) and its medicinal extract called Curcumin (Cúrcuma extracto refinado).

Botanical Classification by Carolus Linnaeus:

  • Family: Zingiberaceae (Ginger, Zenzero, Gingembre, Jengibre, Gengibre)
  • Genus: Curcuma
  • Species: Longa
  • Scientific Name: Curcuma Longa Linnaeus (curcuma longa l)

Distribution:

  • India (especially Andhra Pradesh and Tamil Nadu): 600,000 tons annually .
  • Southeast Asia

The Spice Curcuma/Turmeric

  • Description: a yellow/brown powder made from the dried rhizome of Curcuma Longa. It has a slight earthy flavor and little aroma. It is known for its color and for its health-giving properties.
  • Benefits of Turmeric: a Singapore study of the elderly demonstrated a positive connection between turmeric/curry consumption and cognitive function. People who ate curry often (more than once a month) or ate it occasionally (once or more in 6 months) performed significantly better in mental tests than did those who ate curry less than once a month. (American Journal of Epidemiology 11/2006.)

Use:

  • in Curry powder, Curcuma is added to the mix of spices which usually consist of: coriander, cumin seeds, fenugreek seeds, chili, mustard seeds, black peppercorns and salt.
  • as a tea (for example in Okinawa): turmeric can be added to hot water and then strained (with touch of ginger and lemon juice); it can also be added to milk and simmered.

Description of the Extract: Curcumin/Curcuma

Curcuma is a yellow-orange polyphenol. In its usual form it is a dry yellow powder that is oil-soluble. Curcuma is without flavor and aroma. Its strong anti-oxidant and anti-inflammatory characteristics are its most obvious medicinal properties.

Curcuma is derived from the root of the Curcuma Longa plant first by drying and powdering, to create the spice called Turmeric, then by a solvent extraction. The resulting refined powder is 18 times stronger in the essential ingredients than is the common spice.

Research on Curcuma has been focused on Alzheimer’s, Arthritis, Cancer and Diabetes. In laboratory experiments on rodents, Curcuma can break up the Alzheimer’s amyloid-beta polymers, suppress arthritic inflammation, induce apoptosis in some cancer types and improve insulin sensitivity. Human trials of Curcuma for some illnesses are underway.

Technical Information:

  • Chemical Formula: C21H20O6; Molecular Weight: 368.38
  • Metabolites: Curcumin-sulphate, Curcumin-glucuronide; Catabolites: Vanillic acid and Ferulic acid.
  • Three Molecular Forms: curcumin, demethoxycurcumin and bisdemethoxycurcumin.
  • Molecular structure: it is a dimer of vanillin (2 molecules of vanillin conjoined).

Medicinal Properties of Curcumin:

Curcuma Longa extract has significant effects in the laboratory on arthritis, amyloid-beta (Alzheimer’s polymers), cancer and diabetes. It has the following properties:

  • anti-oxidant;
  • Arthritis: inhibits inflammation, possibly inhibiting something in the pathway of Cox-2 but not Cox-2 itself; not only does it not cause ulcers but is currently being used experimentally as a treatment for ulcers in western countries.
  • Alzheimer’s Disease: inhibits formation of, and breaks down, Amyloid-beta oligomers (entwined fibres) and aggregates (lumps) in rodents;
  • blood thinning: reduces clotting and clinging together of platelets;
  • Cancer: causes apoptosis (death) of various cancer cell types including skin, colon, forestomach, duodenum and ovary in the laboratory; we await clinical trials;
  • inhibits viral and fungal disease;
  • inhibits bacteria including Helicobacter Pylori;
  • Diabetes: reduces diabetes in rodents; we await clinical trials.
  • Summary: “Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses.” – Source: Adv Exp Med Biol. 2007;595:1-75. Curcumin: the Indian solid gold. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

Traditional and Modern Uses of Curcuma Longa

  • In India, Curcuma Longa has been in use as a culinary ingredient since 3000 BC. It is used as a food coloring for curry and as a preservative for food. As a medicine it is used to treat a wide variety of ailments including stomach ache, skin problems, muscular problems and arthritis. Curcuma Longa has also been used as a clothing dye and as a cosmetic. Indians are thought to consume between 80 and 200 mg per day of Curcuma Longa extract. India as a whole consumes 480,000 tons of turmeric annually.
  • In China it has been used as a topical analgesic, and for colic, hepatitis, ringworm and chest pain.
  • In Europe it is used in many foods as a coloring in mustard, cheese, margarine, beverages and cakes. In the recent past it has been used for dyspepsia, chronic anterior uveitis and Helicobacter pylori bacteria.
  • It is generally recognized as safe by the FDA of the United States.
  • Availability: in capsule form as a health supplement and as the culinary spice Turmeric.

As of October 2011 there are more than 4300 articles cited by Pubmed on the subject of Curcuma Longa products including 1604 on cancer, 66 on arthritis, 181 on alzheimer’s disease and 151 on diabetes. This demonstrates that Curcuma Longa is now being used in new ways.

Synonyms for the pure extract:

  • Curcumin; Turmeric Extract; curcuma longa l (English)
  • Curcuma/Cúrcuma (French, Spanish, Portuguese and Italian); also Curcuminé (Fr.)
  • Haldi (हल्दी North India) also Halad, Harida; Manjal (மஞ்சள Tamil) – for the natural spice.
  • Kunyit (Indonesia)
  • Kurkum (الكركم, Arabic)
  • Jiang Huang (姜黄, Chinese)
  • Ukon (ウコン Japanese)
  • diferuloylmethane
  • 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

Source: Youtube, curcumalonga.com

Posted By The Health Cure, June 29 2014

MS & Cannabis – UK Documentary

Cannabis has been wildly successful in treating symptoms of Multiple Sclerosis. Patients all over the world have found much-needed relief from pain, gastrointestinal distress, muscle spasms, and even paralysis thanks to cannabis. But, how can a herb possibly be so effective in treating an incurable neurodegenerative disorder? The answer to this question will amaze you. Here’s how cannabis eases symptoms of Multiple Sclerosis.

Posted By The Health Cure, December 16 2017
Source: Youtube

Raigda Jeha’s Terminal Stomach Cancer Journey

Her name is Raigda Jeha, She is a makeup artist and a mother of 3, at the age of 41 she was diagnosed with terminal stomach cancer Sept. 2015 and she is doing natural/alternative/ and conventional treatments to keep herself alive and thriving….She is sharing her story to help others lead a healthier and cancer free life…and she will share some of her tips about health and wellness.

Hi my name is Raigda Jeha, I am a makeup artist and a mother of 3, at the age of 41 I was diagnosed with terminal stomach cancer Sept. 2015 and I am doing natural/alternative/ and conventional treatments to keep myself alive and thriving….I am sharing my story to help others lead a healthier and cancer free life…and I will share some of my tips about health and wellness. Thank you for subscribing to my channel. Stay healthy and happy.

Follow Raigda’s journey here: https://www.youtube.com/user/raigda74/videos

Source: Youtube
Posted By The Health Cure July 14 2017

Could cannabis oil cure cancer? BBC News

The BBC’s Alastair Leithead reports on how evidence is growing that cannabis could cure diseases like cancer. The medical value of cannabis has been hotly debated for years. Its use as a relaxant or a pain reliever is widely accepted now.

Source: Youtube
Posted By The Health Cure, May 31 2017

The Science of Cannabis as a Treatment for Epilepsy

The Science of Cannabis as a Treatment for Epilepsy

What to do about the medical use of marijuana (cannabis) as a potential treatment for a number of neurologic conditions, including epilepsy, is a hotly debated issue. There are legal issues surrounding access to cannabis, as well as a lack of scientific research on the usefulness and safety of marijuana as a treatment for seizures. Additionally, many different substances containing cannabis are being used which makes it difficult to study.

Does cannabis help seizures?

Evidence from laboratory studies, anecdotal reports, and small clinical studies from a number of years ago suggests that cannabidiol, a non-psychoactive compound of cannabis, could potentially be helpful in controlling seizures. However, there are conflicting reports in the literature. So far, scientifically controlled studies have not shown definitive proof of the effectiveness and safety of marijuana or cannabis in epilepsy. For example, in 2012, a literature review of clinical studies on cannabinoids for epilepsy could not give a reliable conclusion about the effectiveness of four randomized controlled trials of cannabidiol. Yet in the 48 people included in these reports, no side effects were noted. Conducting studies can be difficult as researchers have limited access to marijuana due to federal regulations and even more limited access to cannabidiol; there are also increased financial and time constraints.

Individual reports of children with refractory (or intractable) epilepsy who have tried cannabis, usually with high ratios of cannabidiol to THC, have reported marked improvements in seizure frequency, including a report describing the results of Charlotte, a girl with Dravet syndrome.

Cannabidiol (CBD): Recently, there have been some open-labeled studies in the U.S. of Epidiolex (a drug derived from cannabidiol or CBD), which is produced by a pharmaceutical company (GW Pharmaceuticals). Epidiolex is a purified, 99% oil-based extract of CBD that is produced to give known and consistent amounts in each dose. The U.S. Food and Drug Administration (FDA) has given some epilepsy centers permission to use this drug as “compassionate use” for a limited number of people at each center. Such studies are ongoing for difficult epilepsies such as Lennox-Gastaut syndrome (in children and adults) and Dravet syndrome in children.

Results from 213 people who received Epidiolex (99% CBD) in an open label study (without a placebo control) were presented at the American Academy of Neurology, April 22, 2015 in Washington DC. Data from 137 people who completed 12 weeks or more on the drug were used to look at how helpful or effective the drug was. People who received the Epidiolex ranged from 2 to 26 years old with an average age of 11. All had epilepsy that did not respond to currently available treatments – 25 or 18% had Dravet Syndrome (DS) and 22 or 16% had Lennox-Gastaut Syndrome (LGS).

  • Seizures decreased by an average of 54% in 137 people who completed 12 weeks on Epidiolex.
  • Patients who had DS responded more positively with a 63% decrease in seizures over 3 months.
  • This improvement in seizures lasted through 24 weeks on the Epidiolex, more often for people with DS than without DS.
  • In 27 patients with atonic seizures (which are commonly seen in people with LGS as well as other types of epilepsy), the atonic seizures decreased by 66.7% on average.
  • The responder rate (the number of people whose seizures decreased by at least 50%) was also slightly better in patients with DS (about 55% at 3 months) as compared to patients without DS (50%).
  • People who were also taking the anti-seizure medication Clobazam (Onfi) seemed to respond more favorably to the Epidiolex with a greater improvement in convulsive seizures than in patients who were not taking Clobazam. The authors suggested that an interaction between Clobazam and Epidiolex may play a part in the differences seen.
  • 14 people withdrew from the study because the drug was not effective for them.

A controlled study on on Epidiolex involving many epilepsy centers is now being done that will compare children with Dravet syndrome or Lennox-Gastaut syndrome taking the active drug with children not receiving the drug.

Source: YouTube
The Health Cure, December 12 2016

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